姓名：邓日林

照片：

职称：副教授

主要研究方向：

1.肝癌等消化道肿瘤的免疫治疗，自然杀伤细胞（NK细胞）方向

2.乙型肝炎病毒（HBV）及其致人肝细胞癌（HCC）发生发展机制

3.病毒感染调控先天免疫应答机制

4.抗肿瘤和抗肝炎药物、肿瘤早期诊断试剂盒的研发

邮箱：rl_deng2024@hunnu.edu.cn

个人简历：

邓日林博士，副教授。2020年12月博士毕业于湖南大学生物学院，2021年进入湖南大学生物学博士后流动站工作，并于2024年4月份博士后出站。2024年6月入职问鼎官方· （中国）官方网站,药学院专任教师，2024年12月晋升为副教授。科研项目：主持国家自然科学基金青年项目、中国博士后科学基金面上项目、湖南省自然科学基金青年项目等国家和省部级项目共3项，参与国家自然科学基金重点项目和面上项目、艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项“十三五计划”项目2017年课题等国家和省部级项目共6项。论文发表：发表国内外论文近30篇，其中SCI论文21篇，第一和并列第一作者SCI论文5篇（单篇影响因子达24.1）。

代表性科研项目：

1.2024/01—2026/12：主持国家自然科学基金青年项目“自然杀伤细胞抑制乙型肝炎病毒相关肝细胞癌机制”

2.2022/01—2024/12：主持湖南省自然科学基金青年项目 “H1F0促进病毒诱导先天免疫应答机制”

3.2021/11—2024/04：主持中国博士后科学基金第70批面上项目“先天免疫效应分子ISG12a抑制乙型肝炎病毒相关肝癌机制”

4.2021/01—2024/12：参与研究国家自然科学基金面上项目“NAT9促进病毒诱导先天免疫应答机制”

5.2019/06—2024/04：参与申报“医学病毒学湖南省重点实验室”和相关课题的研究工作

6.2018/01—2022/12：参与申报和研究国家自然科学基金重点项目“丙型肝炎病毒逃逸人肝细胞先天免疫应答而致持续感染机制”

7.2018/01—2024/04：参与申报和研究湖南大学重大横向项目“肝脏疾病诊断试剂及药物研发”

代表性论文（^#为第一或并列第一作者，^*为通讯作者）：

1.Rilin Deng^#, Chaohui Zuo, Yongqi Li, Binbin Xue, Zhen Xun, Yanxia Guo, Xiaohong Wang, Yan Xu, Renyun Tian, Shengwen Chen, Qian Liu, Jinwen Chen, Jingjing Wang, Xiang Huang, Huiyi Li, Mengmeng Guo, Xintao Wang, Miaomiao Yang, Zhihui Wu, Jinfeng Wang, Jiahuan Ma, Jun Hu, Guangdi Li, Songqing Tang, Zhengkun Tu, Hongbin Ji, Haizhen Zhu^*. The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 2020. 17(11): 1163-1179.

2.Rilin Deng^#, Renyun Tian^#, Xinran Li, Yan Xu, Yongqi Li, Xintao Wang, Huiyi Li, Luoling Wang, Biaoming Xu, Di Yang, Songqing Tang, Binbin Xue, Chaohui Zuo, Haizhen Zhu^*. ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis. iScience, 2024. 27: 109533.

3.Rilin Deng^#, Lini Zhang^#, Shengwen Chen, Xinran Li, Binbin Xue, Huiyi Li, Yan Xu, Renyun Tian, Qian Liu, Luoling Wang, Shun Liu, Di Yang, Penghui Li, Songqing Tang, Haizhen Zhu^*. PZR suppresses innate immune response to RNA viral infection by inhibiting MAVS activation in interferon signaling mediated by RIG-I and MDA5. Antiviral Research, 2024, 222: 105797.

4.Jinfeng Wang^#,Rilin Deng^#, Shuai Chen, Shun Deng, Qi Hu, Biaoming Xu, Junjun Li, Zhuo He, Mingjing Peng, Sanlin Lei, Tiexiang Ma, Zhuo Chen, Haizhen Zhu, Chaohui Zuo^*. Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes. iScience, 2023, 26(12):108414.

5.Rilin Deng^#, Bin Liu, Yan Wang, Feng Yan, Shifan Hu, Hongcan Wang, Tingting Wang, Bin Li, Xiyun Deng, Shuanglin Xiang, Yinke Yang^*, Jian Zhang^*. High expression of the newly found long noncoding RNA Z38 promotes cell proliferation and oncogenic activity in breast cancer. Journal of Cancer, 2016, 7(5): 576-86.

6.Luoling Wang^#,Rilin Deng, Shuishun Chen, Renyun Tian, Mengmeng Guo, Zihao Chen, Yingdan Zhang, Huiyi Li, Qian Liu, Songqing Tang^*, Haizhen Zhu^*. Carboxypeptidase A4 negatively regulates HGS-ETR1/2 induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway. Cell Death & Disease, 2023, 14(12): 793.

7.Yongqi Li^#, Yang Yang, Tianyang Li, Zhengmin Wang, Chunfeng Gao,Rilin Deng, Faxiang Ma, Xinyang Li, Licong Ma, Renyun Tian, Huiyi Li, Haizhen Zhu, Lei Zeng, Yanhang Gao, Guoyue Lv, Junqi Niu, Ian Nicholas Crispe, Zhengkun Tu^*. Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection. Journal of Virology, 2023, 97(10): e0109023.

8.Huiyi Li^#, Shun Liu, Qing Feng,Rilin Deng, Jingjing Wang, Xintao Wang, Renyun Tian, Yan Xu, Shengwen Chen, Qian Liu, Luoling Wang, Xinran Li, Mengyu Wan, Yousong Peng, Songqing Tang, Binbin Xue^*, Haizhen Zhu^*. Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress. PLOS Pathogens, 2023, 19(6): e1011443.

9.Cong Wang^#, Xue Li^#, Binbin Xue^#, Changping Yu^#, Luoling Wang^#,Rilin Deng, Hui Liu, Zihao Chen, Yingdan Zhang, Suping Fan, Chaohui Zuo, Hungyu Sun, Haizhen Zhu^*, Jianli Wang^*, Songqing Tang*. RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth. Nature Communications, 2022, 16;13(1):7001.

10.Binbin Xue^#, Huiyi Li^#, Shun Liu, Qing Feng, Yan Xu,Rilin Deng, Shengwen Chen, Jingjing Wang, Xinran Li, Mengyu Wan, Songqing Tang, Haizhen Zhu^*. The redox cycling of STAT2 maintains innate immune homeostasis. Cell Reports, 2022, 16;40(7): 111215.